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KMID : 0191120090240040747
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Journal of Korean Medical Science
2009 Volume.24 No. 4 p.747 ~ p.750
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A Case of Wernicke’s Encephalopathy Following Fluorouracil-based Chemotherapy
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Cho In-Jeong
Chang Hye-Jung
Lee Kyung-Eun
Won Hye-Sung
Choi Moon-Young
Nam Eun-Mi
Mun Yeung-Chul
Lee Soon-Nam
Seong Chu-Myong
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Abstract
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The pyrimidine antimetabolite 5-fluorouracil (5-FU) is a chemotherapeutic agent used widely for various tumors. Common side effects of 5-FU are related to its effects on the bone marrow and gastrointestinal epithelium. Neurotoxicity caused by 5-FU is uncommon, although acute and delayed forms have been reported. Wernicke’s encephalopathy is an acute, neuropsychiatric syndrome resulting from thiamine deficiency, and has significant morbidity and mortality. Central nervous system neurotoxicity such as Wernicke’s encephalopathy following chemotherapy with 5-FU has been reported rarely, although it has been suggested that 5-FU can produce adverse neurological effects by causing thiamine deficiency. We report a patient with Wernicke’s encephalopathy, reversible with thiamine therapy, associated with 5-FU-based chemotherapy.
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KEYWORD
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Fluorouracil, Wernicke’s Encephalopathy, Thiamine
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